Chemical composition and biological activities of Valeriana dioscoridis SM. roots

Zika, dengue, and Yellow fever are transmitted primarily by Aedes aegypti mosquitoes. Investigations to find more natural but highly effective pesticidal agents against Ae. have increased in the last few years. Plant-based compounds been source of several current pesticides provided models for creation synthetic derivatives like pyrethroids. Plants continue be a rich potential new active ingredients. The aim this study is increase knowledge on V. dioscoridis present results cytotoxic insecticidal activities various extracts its roots volatile compound compositions roots. hexane chloroform extracts, HM1 CM1 respectively, exhibited cytotoxicity with IC50 values 128.4 86.93 µg/mL HepG2 cell line. Because had higher across studied concentration range, it was also tested HUVEC Extracts were their activities. found (mortality (%) = 96.7% ± 5.8 at 5 μg/mosquito), consistent activity. Since these nonpolar, chemical composition analyzed GC-MS analysis. About 87.7% essential oil characterized. major ß-eudesmol (9.2%), following camphene (8.9%), bornyl acetate (8.2%) maaliol (7.6%). This first activity dioscoridis. Further studies plant define spectrum examine therapeutic warranted.